Epigenetics

L'UE 'Epigenetics' de Master 1 est proposée par le Master Biologie-Santé de l'Université Paris-Saclay.

Cette UE est limitée à 50 étudiants max. 

Les cours et conférences sont donnés en anglais. Durant les TD  les étudiants sont répartis en 2 groupes, l'un en anglais, l'autre en Français.

Description of the course:

This course will deepen the notions of epigenetics discussed in the Master 1 core course (Socle M1).  

During this course, the following topics will be discussed:

• How epigenetic mechanisms impact on gene expression controls, how they structure and regulate three-dimensional compaction of the genome and how they can be altered in human pathologies, like cancers .
  
• How several layers of epigenetic mechanisms are integrated during development, using the example of X-chromosome inactivation 
  
• How epigenetic memory is setup during differentiation and erase during stem cells reprogramming?
  
• How epigenetic traits can be transmitted based on self-templating structural inheritance, using the example of prions.

Additional examples of integrated epigenetic mechanisms (at the organism or population levels) will be presented by invited researchers. These lectures will address the cast and sexual polyphenisms in honey bees and aphids; the impact of nutrition on metabolic diseases and cancers, the hijacking of the host’s epigenetic machinery during bacterial infection, …

At the end of this course, the students should be able to :

(1) Name, describe and discuss the different epigenetics layers impacting on gene expression levels

(2) Analyze and interpret epigenetic and epigenomic figures

(3) Portray and detail few integrated examples of epigenetic inheritances